Scientist I, DMPK

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

Specifically, you will:

• Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples (blood, plasma, tissue, urine, bile, etc.), and perform metabolite profiling and structural elucidation.

• Characterize major, unique, or disproportionate metabolites to support candidate selection, MIST (Metabolites in Safety Testing) analysis, and metabolite regulatory strategy.

• Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities.

• Develop and apply PBPK models to predict human DDI risk potential using preclinical dataset; support regulatory interactions related to PBPK-based DDI modeling strategies.

• Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.

• Build and maintain strong collaborative partnerships across functional areas, e.g., Discovery research, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.

Required Skills, Experience and Education:

• A highly motivated individual with a PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, with 0- 2 years of experience after graduation.

• Solid understanding of drug metabolism, pharmacokinetics, and ADME principles.

• Excellent verbal and written communication, problem-solving and critical thinking skills.

• Ability to independently design experiments, analyze data, and communicate results.

Preferred Skills:

• Prior experience in metabolite profiling using high resolution mass spectrometry is highly preferred.

• Prior experience with oncology drug discovery is preferred.

• Familiar with PBPK modeling software (e.g. WinNonlin, Simcyp, Gastroplus).

• Effective communication and documentation skills.

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