Executive Director, Head of Information Technology, Japan

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking an experienced IT Leader to establish and oversee the set up and execution of all aspects of IT operations in Japan. This role will serve as the primary technology partner for business functions in Japan, also acting as the bridge between local stakeholders and global Information Sciences (IS) and Information Technology (IT) teams ensuring that IS/IT needs are met in alignment with global platforms, delivering end-to-end solutions for local implementation while driving operational excellence in IS/IT services. This leader may also help build and scale the IT function to other countries in the Asia Pacific region through a balanced model of internal team development and strategic vendor partnerships to deliver agile, high-quality support across the region.

Reporting directly to the President & Representative Director, Japan, this individual will collaborate closely with country and regional leaders as well as global Information Sciences and Information Technology (IS/IT) partners. The role also dotted-line reports to the VP, Commercial & Medical Affairs Information Systems. The position requires versatility—balancing the establishment of local capabilities with the development of scalable solutions that integrate seamlessly into global frameworks.

Commercial and Medical Affairs Systems

• Serve as the primary liaison between Japan and global Information Systems teams, fostering cross-functional collaboration while maintaining data governance and separation of processes.

• Partner with business leaders to develop prioritized roadmaps and capture requirements, ensuring alignment with global IS/IT platform roadmaps while tailoring solutions to country/regional needs.

• Act as an effective liaison by proactively communicating priority needs for the APAC/Japan region and working closely with other regions to align on shared priorities, expectations, and consistent working norms.

• Support rollout, localization, and adoption of global platforms (e.g., CRM, digital engagement, Omnichannel marketing, medical information, medical content management, field engagement tools).

• Partner with local Commercial, Supply Chain and Quality teams to ensure IS/IT systems supporting product distribution, logistics, and product release operate reliably and comply with local regulatory standards.

• Oversee localization and validation of IS/IT systems to meet Japan-specific business and regulatory needs, including language, documentation, and integration with local platforms.

• Provide Tier 1–2 application support in partnership with global support teams, ensuring seamless end-to-end service delivery.

• Lead change management for new IS/IT systems, including user testing, training, communications, and stakeholder alignment to ensure successful adoption and continuous improvement.

Information Technology and Security

• Establish and manage relationships with local managed service providers and vendors.

• Collaborate with global IT infrastructure teams to ensure reliable and secure delivery of core IT services (network, hardware, collaboration platforms, endpoint management).

• Oversee system enhancements, integrations, and facilitate compliance with Japanese data production and pharmaceutical regulations, including pharmacovigilance, promotional review, and data privacy (APPI, PMD Act).

• Manage onboarding and offboarding processes, ensuring timely provisioning/deprovisioning of accounts and devices aligned with local and global IT policies and security standards.

• Ensure adherence to global IT service management and change control processes, including incident, request, and problem management, while coordinating escal