Sr Staff Bioinformatics Scientist - Cancer/Oncology Genomics

Help turn cancer genomes into clinical answers

At Illumina, our work has the power to change lives. By unlocking the information in the genome, we enable clinicians and researchers to move faster, see deeper, and make better decisions for patients.

We are looking for a Senior Staff Bioinformatics Scientist to join our Clinical Translational Research team — a role for someone who has considerable experience in Cancer Genomics and thrives at the intersection of cutting‑edge science, real‑world clinical impact, and collaborative innovation.

You’ll play a pivotal role in advancing the adoption of whole genome sequencing (WGS) in oncology, helping to translate complex cancer genomes into actionable insights for clinical practice.

What you’ll do

In this highly visible and autonomous role, you will act as a scientific leader and trusted expert, shaping both analysis strategy and product direction:

• Lead and deliver expert bioinformatics analysis of tumour whole genome sequencing data, improving quality, success rates, and clinical relevance in partnership with internal teams and external collaborators
• Collaborate with customers, academic partners, and key opinion leaders to analyse cancer genomics data and accelerate adoption of emerging Illumina technologies
• Provide subject‑matter expertise to inform and improve Illumina’s bioinformatics pipelines, interpretation software, and end‑to‑end oncology workflows
• Evaluate and integrate novel tools and algorithms, translating scientific innovation into software prototypes with real clinical value
• Contribute to scientific collaborations, publications, and thought leadership in cancer genomics

You’ll work with a high degree of initiative, ownership, and trust, while being deeply connected to a network of world‑class scientists, clinicians, and product teams.

Who you are

You are a curious, collaborative, and impact‑driven scientist who enjoys solving complex problems and sharing knowledge. You’re comfortable operating in fast‑moving environments and presenting sophisticated ideas to diverse audiences.

You will bring:

• A PhD in cancer genomics with significant postdoctoral or industry experience, or a Master’s degree with extensive relevant experience and a strong publication record
• Deep expertise in cancer whole genome sequencing, including QC, variant calling, bioinformatics analysis, and clinical interpretation (essential)
• Experience with cohort analysis and cancer biomarker discovery (desirable)
• Strong programming and computational skills: R and/or Python, Unix/Linux, git, HPC environments (essential)
• Familiarity with Illumina DRAGEN pipelines and interpretation tools (desirable)
• Excellent communication skills, with the ability to engage clinicians, academics, and industry stakeholders alike
• The drive to succeed in a fast‑paced, innovative, and competitive environment

Why Illumina

At Illumina, we believe innovation happens when diverse perspectives come together, when curiosity is encouraged, and when people feel empowered to do their best work. We are committed to:

• Innovating with purpose with real patient impact
• Making our customers heroes across disciplines, cultures, and geographies
• Integrity, inclusion, and respect in everything we do
• Creating an environment where talented people can grow, lead, and belong

If you’re excited by the idea of shaping the future of clinical cancer genomics — and doing it alongside people who care deeply about science, patients, and each other — we’d love to hear from you.