Scientist I, Stem Cell Genomics, CELLxSTATE

The Team

Biohub is a 501(c)(3) biomedical research organization building the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease. We build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With our compute capacity, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, we are enabling scientists worldwide to use AI-powered biology to advance our understanding of human health. 

Through our multi-dimensional imaging program, we build imaging tools that capture life across scales — from single proteins to whole organisms — revealing how proteins and cells function, communicate, and assemble into living systems. These observations are laying the groundwork for a new generation of AI models that can predict cellular behavior and guide the development of better treatments for widespread diseases. You can learn more about our work here. 

Our work brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. 

Our Vision

• Pursue large scientific challenges that cannot be pursued in conventional environments
• Enable individual investigators to pursue their riskiest and most innovative ideas
• Facilitate research by scientists and clinicians at our home institutions and beyond

We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.

The Opportunity

Part of Imaging Grand Challenge, the CELLxSTATE Program is building next-generation technologies to decode and control how cells make decisions, combining live-cell imaging, multi-omics, and AI at unprecedented scale. At the core of our current effort is multiDPS (Multimodal Dynamic Pooled Screening), a high-throughput platform that integrates custom microscopy, automation, CRISPR screening and molecular profiling to map and predict dynamic cell states. As part of this effort, the Intracellular Architecture team at the CZ Biohub San Francisco is building scalable technologies to map the molecular architecture of human cells, how it changes in disease, and how we can control it. 

For this we combine genome engineering, fluorescence microscopy, proteomics, robotics, software engineering and data science. We build large datasets and use them to draw new biological insights. For example, our OpenCell project provides a large reference of protein localization and interactions that can be mined and re-used by the entire community for discovery. Our science is fully open-source and published in journals like Science, Nature Methods, and Cell.

We are seeking a Scientist I to advance our Stem Cell Genomics efforts within the CELLxSTATE program. The successful candidate will develop and implement single-cell and multi-omics approaches in human stem cell systems, and integrate these with CRISPR-based perturbation and high-content imaging platforms. This role focuses on building scalable, high-throughput experimental workflows to enable multimodal p