Computational Biologist II – Immune Cell Development
Confirmed live in the last 24 hours
CZ Biohub
Compensation
$153,000 - $210,100
Job Description
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub in New York is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.
Our Vision
- We pursue large scientific challenges that cannot be pursued in conventional environments
- We enable individual investigators to pursue their riskiest and most innovative ideas
- The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond
Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
The Opportunity
The van der Stegen Lab at Biohub NY studies human immune cell development from induced pluripotent stem cells and designs engineering strategies to harness immune cells for therapeutic applications. We are looking for a Computational Biologist to join our team to further expand our evaluation of immune cell lineage commitment, function and how genetic engineering strategies can affect those.
The Computational Biologist will possess deep expertise in the analysis of single cell transcriptional data, including developmental trajectory analysis, and ideally also have experience with proteomics datasets. They have an interest in hematopoiesis and immune cell biology and can demonstrate the intention to apply state-of-the-art analysis tools through close collaboration with the data science team at Biohub.
What You'll Do
- Implement and create analytical pipelines for transcriptomics, including chemical and/or genetic perturbations, and multi-omic datasets
- Support immunologists in experimental design for transcriptomic and multi-omic analysis
- Support immunologist in the experimental design of CRISPR screens
- Analyze scRNAseq, CITE-seq, scATACseq, TCR/BCRseq and Mass Spectrometry datasets
- Incorporate publicly available datasets with in-house generated datasets
- Support new hypothesis generation
- Present research findings in academic journals and conferences
What You'll Bring
- PhD degree in computational biology, systems biology, immunology,
