Staff Software Engineer – Data Team (Durham, NC) #4433

Confirmed live in the last 24 hours

GRAIL

Durham, NC

Hybrid

Posted December 3, 2025

Job Description

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

GRAIL is seeking a Staff Software Engineer for the Data Team. This team designs, builds, and operates the software systems that manage GRAIL’s end-to-end data lifecycle, from sample ingestion through downstream analysis, while meeting rigorous clinical, regulatory, and privacy standards. Our work directly supports clinical research, operations, and decision-making in the fight against cancer.

In this role, you will take technical ownership of systems that produce trusted, analysis-ready datasets for use across GRAIL’s research and clinical programs. This is a software engineering role focused on building complex production-grade systems that work with data in dynamic, regulated environments as opposed to assembling off-the-shelf ETL tools or writing SQL heavy pipelines,.This position offers significant autonomy and scope for impact. You’ll collaborate closely with research, clinical lab operations, and scientific teams, and lead efforts to improve how we structure, validate, and deliver critical scientific and clinical data.

This is a hybrid role based in either Menlo Park, CA (moving to Sunnyvale, CA in Fall 2026) or Durham, NC. Our current hybrid policy requires on-site presence at least 60% of the time, including key in-person collaboration days.

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