About the role

Aplyr's Quick Take

This role is for a Principal Scientist focused on clinical biomarkers in immunology and hematology, primarily working on novel therapies and their mechanisms of action. You'll be leading biology aspects on project teams and driving biomarker strategies, making this an individual contributor position with significant responsibility.

Good fit

Ideal candidates have a strong background in immunology or hematology, with several years of experience in clinical research or biomarker development. A collaborative working style and the ability to lead cross-functional teams will be essential.

Worth noting

This is a contractor position for 12 months, which may appeal to those looking for flexibility or project-based work. The focus on hematological malignancies suggests a specialized niche that may limit the pool of suitable applicants.

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology, Immuno-Oncology, & Hematology (Contractor) as part of the Research & Development team based in Somerset, NJ.

Role Overview

We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.

Contract Duration: 12 months

Key Responsibilities

Scientific Leadership: Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
Translational Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
Understanding MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
Cross-Functional Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology

Requirements

Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies. Experience with cell therapy a plus but not required.
A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology highly desirable.
Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
Experience working with multiple dimensional data, extract biological insights from data highly desirable.
Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.

Skills & Tags

go aws data design

Aplyr's read

Legend Biotech pioneers cell therapies for cancer, attracting specialists in research, clinical development, and strategic alliances to advance groundbreaking treatments.
Synthesized from recent postings & public sources

What's promising

•Legend Biotech is at the forefront of cell therapy innovation for cancer treatment.
•The company offers diverse roles from research to strategic alliances, appealing to a wide range of professionals.
•Strong focus on clinical development and commercialization of advanced therapies.

What to watch

•Biotechnology sector faces high regulatory scrutiny, impacting timelines and costs.
•Intense competition in the cell therapy space may affect market share.
•Dependence on successful clinical trials for future growth and stability.

Why Legend Biotech

•Specializes in innovative CAR-T cell therapies for cancer.
•Operates globally, providing opportunities for international collaboration and growth.
•Focuses on both research and commercialization, bridging scientific discovery with market application.

Aplyr’s read is generated by AI from public sources. Was it useful?