Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency.

Days Onsite: Monday & Tuesday

Summary:

The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Responsibilities:

• Design and develop novel cell-free technologies and products
• Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays
• Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features
• Synthesize large datasets to develop and evaluate new biological and technological hypotheses
• Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements
• Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space
• Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements:

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