About the role

Aplyr's Quick Take

This role is about managing daily operations in a busy lab focused on high-throughput chemistry and GMP processes. You'll handle supply management, chemical inventory, and vendor relationships, reporting to the Senior Laboratory Manager. It's an individual contributor position that requires hands-on experience in laboratory settings.

Good fit

Candidates with 3-5 years of experience in laboratory operations, especially in high-hazard environments, will thrive here. A detail-oriented and adaptable person who communicates well across teams will do best.

Worth noting

The role involves managing high-volume, high-hazard chemicals, which may not be suitable for everyone. The emphasis on operational excellence suggests a fast-paced environment that may require quick problem-solving skills.

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Position Summary

We are seeking a highly motivated Senior Laboratory Operations Associate with 3–5 years of hands-on experience supporting high-throughput, high-hazard chemistry, vivarium, and GMP operations. This individual will play a critical role in ensuring the smooth operation of a dynamic laboratory environment. The ideal candidate has a deep understanding of management of high-volume high hazard chemicals, asset management, is adaptable, detail-oriented, and a strong cross-functional communicator with a passion for operational excellence.

Key Responsibilities

· Under the guidance of the Senior Laboratory Manager, manage day-to-day operations in high-volume chemistry, biology, animal, and GMP laboratories, including supply management, asset management, chemical inventory, and waste handling.

· Oversee management and administration of laboratory instrument service agreements, remedial repair, scheduling preventative maintenance, and digital asset management system.

· Manage relationship with select vendors and suppliers.

· Oversee the receipt, organization, and distribution of reagents and consumables to support chemistry workflows including 55-gallon drums of virgin chemicals and waste.

· Ensure appropriate segregation, labeling, storage, and disposal of high-hazard chemicals, including Class A, Class B, water reactive materials, organic acids, inorganic acids, bases, and acutely toxic chemicals.

· Coordinate with chemists to prepare and dispose of solid-phase resins, solvents, and purification materials in compliance with EHS protocols.

· Monitor and maintain process systems and chemicals in 780 CMR/International Building Code (IBC) §307 designated High-Hazard Group Occupancy (H3 room).

· Collaborate with vivarium staff to support animal research workflows, including supply delivery, sanitization cycles, live animal deliveries, and carcass disposal in accordance with 105 CMR 480.000.

· Support cross-functional workflows between R&D and GMP labs.

· Ensure documentation, materials movement, and environmental monitoring align with GMP compliance expectations.

· Other responsibilities as required.

Qualifications

Education & Experience

· 3–5 years of direct hands-on experience in laboratory operations within a biotechnology environment.

· Experience supporting high-hazard chemistry, vivarium operations, GMP manufacturing, and BSL-2 biology labs.

Required Skills & Competencies

· Experience working in ISO 5, 7, and 8 cleanroom environments.

· Experience with ‘just-in-time’ supply chain management, KANBAN, 5S/Lean.

· Familiarity with lab and facility management systems (e.g., LIMS, CMMS, asset management).

· Comfortable working in environments requiring strict compliance: H3 occupancy, BSL-2, vivarium, and GMP.

· Strong organizational and multitasking skills with an ability to work independently.

· Excellent communication skills, both verbal and written.

· Familiarity with 527 CMR 1.00, RCRA, EPA, DOT, HAZWOPPER, and IATA regulations.

Physical Requirements

· Ability to be on-call to receive and respond to alarms within 1 hour.

· Ability to lift 50lbs, stand for extended periods, and perform repetitive physical tasks.

· Comfortable working with hazardous materials while wearing appropriate PPE including the Advantage 420 Respirator, Tyvek Full GMP Sterile Coverall, lab coat, and ‘silvershield’ gloves.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range

$82,010—$113,300 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Skills & Tags

react ai data design

Aplyr's read

Prime Medicine is pioneering gene-editing technologies with a focus on precision and safety, attracting scientists and innovators passionate about transforming healthcare.
Synthesized from recent postings & public sources

What's promising

•Prime Medicine is at the forefront of gene-editing technology, offering cutting-edge solutions in healthcare.
•The company has attracted top talent in AI and informatics, enhancing its research capabilities.
•Prime Medicine's focus on safety assessment and DMPK highlights its commitment to drug safety and efficacy.

What to watch

•The gene-editing field is highly competitive, posing challenges for Prime Medicine to maintain its market position.
•Regulatory hurdles in gene-editing can delay product development and market entry.
•Limited public information about the company's financial stability and long-term viability.

Why Prime Medicine

•Prime Medicine's emphasis on precision gene-editing sets it apart in the biotechnology sector.
•The integration of AI in their research processes enhances the accuracy and efficiency of their scientific endeavors.
•A strong focus on culture and people development is evident with roles like Director, People and Culture Business Partner.

Aplyr’s read is generated by AI from public sources. Was it useful?