Principal / Sr. Principal - In Vivo Biologist, Cardiometabolic Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Cardiometabolic Research (CMR) Therapeutic Area of Eli Lilly and Company, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of cardiometabolic diseases and associated complications. The cardiorenal team is looking for a biologist to conduct experiments using animal models of cardiorenal and cardiometabolic diseases. The applicant must be a task-oriented and self-motivated worker who can perform detailed research studies with minimal supervision. The applicant will design and perform experiments independently and within team-based environments, as well as interact with internal and external collaborators.  The successful candidate will actively participate in heart failure and atrial fibrillation drug hunting teams - serving as a scientific and technical advisor to project teams.

Key Responsibilities

• Develop and validate rodent cardiovascular models, with emphasis on atrial fibrillation and heart failure.
• Conduct acute, subacute, and chronic in vivo studies using animal models relevant to heart failure, atrial fibrillation, and cardiometabolic diseases.
• Execute laboratory procedures including animal handling, collection of blood, urine, and biopsy samples, as well as measurement of body weight, food intake, and blood pressure.
• Prepare test article formulations and administer them by oral gavage and various parenteral routes such as subcutaneous, intravenous, intraperitoneal, and intramuscular injections.
• Perform small animal surgical techniques, including survival and non-survival procedures, with specialization in unilateral uninephrectomy, osmotic pump insertion, rodent vessel cannulation, and pressure-volume loop assessments.

• Perform analysis and interpretation of data from in vivo experiments, including presentation of data in spreadsheet and graphical form with descriptive statistical analysis.

• Maintain precise records, perform thorough data analysis, and report findings in both written and oral forms.
• Demonstrate ability to mentor and guide laboratory staff and ensure the lab maintains compliance with safety guidelines.
• Ensure all activities comply fully with Lilly Research Policies and complete all mandatory training within the designated timeframe.
• Exhibit proactive and adaptable behavior while developing competencies essential for independent research project execution.

Minimum Requirements

• Masters in biology, pharmacology or related discipline with 3 or more years of relevant experience OR
• Bachelors degree, pharmacology or related discipline with 5 or more years of relevant experience
• Experience with in vivo studies and the handling of small laboratory animals.
• Flexible scheduling is a requirement. The position is full-time (40 hrs/wk), but not all regularly scheduled work hours will occur Mon-Fri from 7:30 AM-4:15 PM.  There is a requirement to work occasionally early and/or after-hours or on weekends.

• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Additional Skills/Preferences

• Familiarity with RNA detection methods and hands-on experience with ELISA or qPCR.
• Experience with Microsoft Word, Excel and PowerPoint as well as with graphing and statistics using JMP or GraphPad Prizm.
• Applicants should be able to arrange, modify and organize methods for in vivo studies and modify procedures when warranted.
• Willingness to work with radioisotopes, chemical, and biological hazards.
• Oral/written communication/listening skills are essential.
• Strong relationship-building and interaction skills with peers and management.

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$65,250 - $169,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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