Manager, Biospecimen Operations, Translational Medicine

Confirmed live in the last 24 hours

Revolution Medicines

Compensation

$143,000 - $178,000/year

Redwood City, California, United States

Hybrid

Posted April 10, 2026

Job Description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Playing a critical role as a Manager, Biospecimen Operations within Translational Medicine function, the position will be providing biomarker operational expertise in, developing scope of work, and maintaining effective working relationships with cross-functional teams for phase three clinical trials.

Lead end‑to‑end biomarker operations across Phase I–III oncology clinical trials, including protocol reviews, prospective testing strategies, sample lifecycle oversight, data management, query resolution, and vendor qualification and contracting.
Collaborate cross‑functionally with Biomarker Leads, Companion Diagnostics, Clinical Operations, and Data Management on reviews of protocol, ICF, eCRF, DTS, Genomic Verification Forms, and eTMF documentation to ensure operational alignment.
Oversee central lab activities, including operational lab startup, lab manual and site requisition form, SOW reviews and budget evaluation.
Manage relationships with specialty biomarker labs, including sample logistics oversight, testing strategy alignment, RUO data transfer execution, issue and query resolution, invoice review, and coordination of recurring operational meetings.
Contribute to SOP development, operational process optimization, and biomarker program initiatives to support biomarker operation excellence.
Support TM deliverables, including IA data reviews, CSR, and regulatory submissions for CDx filings.
Drive vendor selection, qualification, onboarding, and participate in audits to ensure adherence to regulatory and quality standards.
Provide biomarker operational metrics and study updates to cross‑functional teams and senior leadership to support strategic decision‑making
Review ICFs and respond to EC and IRB inquiries related to biomarker components.
Collaborate closely with Pharmacokinetic (PK) Leads to support PK operations and ensure timely delivery of all PK‑related clinical milestones.
Bring experience in diagnostic operations supporting CDx development and regulatory filings, including sPMA submissions.
Utilize IRT and EDC systems to enable real‑time sample tracking, data integration, and prompt query resolution.

Required Skills, Experience and Education:

Life sciences degree (BS or MS) in scientific, medical, healthcare, or related discipline.
7+ years related professional experience in a clinical research setting, clinical/diagnostic laboratory.
Should have experience mentoring team members.
Prior experience in clinical biomarker and CDx operations in phase one to three clinical trials is strongly preferred.
Prior experience in TruTech, SLOPE and LIMS platforms is highly desirable.
Excellent scientific and business communication skills, strong interpersonal/collaboration skills, and planning skills.
Should be proficient in Microsoft Excel, Microsoft PowerPoint applications.
Experience in using Project Management tools is highly desired.
Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems.
Ability t