Senior Bioinformatics Scientist

We are looking for a highly motivated Senior Bioinformatics Scientist to join our Oncology Applications team!

As a Senior Bioinformatics Scientist, you will develop and apply computational methods for analyzing next-generation sequencing (NGS) data generated on Ultima’s platform. This role will involve building robust pipelines, developing novel algorithms, collaborating cross-functionally with molecular biology, software engineering, and product teams, and driving insights from complex genomic datasets, with a focus on growing Oncology Applications.

This position is ideal for someone who thrives in a dynamic, fast-paced environment and can effectively balance multiple high-impact projects. In addition to core R&D responsibilities, you will contribute to external-facing scientific communications and support collaborations with customers and partners.

How You’ll Contribute

• Develop, optimize, and maintain scalable bioinformatics pipelines for NGS data analysis such as WGS, WES, RNA-seq, and single-cell
• Design and implement novel algorithms for secondary and tertiary NGS analysis tailored to Ultima’s sequencing chemistry
• Lead and execute multiple projects simultaneously, effectively prioritizing deliverables in alignment with evolving company goals
• Perform benchmarking and validation studies
• Analyze large-scale genomic datasets and generate actionable insights for internal R&D, product development, and external collaborators
• Collaborate closely with wet-lab scientists, software engineers, and product teams to translate experimental results into improved workflows and tools
• Support external collaborations by preparing technical analyses, reports, presentations, and data summaries for customers, partners, and conferences
• Contribute to scientific publications, application notes, white papers, and other external communication materials as needed
• Participate in customer-facing discussions to explain data analysis approaches, performance metrics, and platform capabilities
• Document methods clearly and communicate findings effectively to both technical and non-technical audiences
• Stay current with emerging technologies and advances in genomics, computational biology, machine learning, and cancer biology
• Other duties as assigned

Qualifications, Skills, Knowledge & Abilities

• PhD in Bioinformatics, Computational Biology, Genomics, Computer Science, or related field; or MS with significant industry experience
• PhD with 2+ years or MS with 5+ years of hands-on experience analyzing NGS data is required
• Strong programming skills in Python and/or C++
• Experience with common bioinformatics and somatic variant calling tools such as BWA, minimap2, GATK, samtools
• Proficiency in Linux/Unix environments and workflow management systems (Nextflow, Snakemake, WDL)
• Experience working with large datasets in cloud environments (AWS, GCP)
• Solid understanding of genomics and cancer biology
• Strong statistical and data analysis skills
• Demonstrated ability to manage multiple concurrent priorities and deliver high-quality work under tight timel